Resveratrol and exercise: a review on the effects of resveratrol on physical and sport performance
uma revisão sobre os efeitos do resveratrol no desempenho físico e esportivo
DOI:
https://doi.org/10.33837/msj.v6i1.1593Keywords:
Aerobic exercise, Exercise, Resveratrol, SupplementationAbstract
Phenolic compounds have been shown to be important molecules in human metabolism. Among these, resveratrol, found primarily in the skin of red grapes, has been touted as a promising adjuvant in the treatment and prevention of disease. Recently, the ergogenic potential of resveratrol has been investigated, however, showing diverging results. The purpose of this review was to analyze and discuss studies that evaluated the effects of resveratrol supplementation on exercise performance. The search terms resveratrol, physical exercise and exercise training on the PubMed platform were used, resulting in 18 studies eligible for the selection criteria. The selected studies confirm that there is no consensus in the scientific literature about the ergogenic potential of resveratrol. The selected studies do not point to a common result, and even similar experimental interventions show divergent results.
References
Alway, S. E., McCrory, J. L., Kearcher, K., Vickers, A., Frear, B., Gilleland, D. L., … Lively, M. W. (2017). Resveratrol enhances exercise-induced cellular and functional adaptations of skeletal muscle in older men and women. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 72(12), 1595–1606.
Dolinsky, V. W., Jones, K. E., Sidhu, R. S., Haykowsky, M., Czubryt, M. P., Gordon, T., & Dyck, J. R. (2012). Improvements in skeletal muscle strength and cardiac function induced by resveratrol during exercise training contribute to enhanced exercise performance in rats. The Journal of Physiology, 590(11), 2783–2799.
Gliemann, L., Schmidt, J. F., Olesen, J., Biensø, R. S., Peronard, S. L., Grandjean, S. U., … Pilegaard, H. (2013). Resveratrol blunts the positive effects of exercise training on cardiovascular health in aged men. The Journal of Physiology, 591(20), 5047–5059.
Golan, R., Gepner, Y., & Shai, I. (2019). Wine and health–new evidence. European Journal of Clinical Nutrition, 72(1), 55–59.
Gomez-Cabrera, M.-C., Domenech, E., Romagnoli, M., Arduini, A., Borras, C., Pallardo, F. V., … Vina, J. (2008). Oral administration of vitamin C decreases muscle mitochondrial biogenesis and hampers training-induced adaptations in endurance performance–. The American Journal of Clinical Nutrition, 87(1), 142–149.
Guerrero, R. F., Garcia-Parrilla, M. C., Puertas, B., & Cantos-Villar, E. (2009). Wine, resveratrol and health: A review. Natural Product Communications, 4(5), 1934578X0900400503.
Hart, N., Sarga, L., Csende, Z., Koch, L. G., Britton, S. L., Davies, K. J., &Radak, Z. (2014). Resveratrol attenuates exercise-induced adaptive responses in rats selectively bred for low running performance. Dose-Response, 12(1), dose-response.
Hart, N., Sarga, L., Csende, Z., Koltai, E., Koch, L. G., Britton, S. L., … Radak, Z. (2013). Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food and Chemical Toxicology, 61, 53–59.
Hecker, A., Schellnegger, M., Hofmann, E., Luze, H., Nischwitz, S. P., Kamolz, L., &Kotzbeck, P. (2022). The impact of resveratrol on skin wound healing, scarring, and aging. International Wound Journal, 19(1), 9–28.
Huang, C.-C., Lee, M.-C., Ho, C.-S., Hsu, Y.-J., Ho, C.-C., & Kan, N.-W. (2021). Protective and recovery effects of resveratrol supplementation on exercise performance and muscle damage following acute plyometric exercise. Nutrients, 13(9), 3217.
Kan, N.-W., Ho, C.-S., Chiu, Y.-S., Huang, W.-C., Chen, P.-Y., Tung, Y.-T., & Huang, C.-C. (2016). Effects of resveratrol supplementation and exercise training on exercise performance in middle-aged mice. Molecules, 21(5), 661.
Kan, N.-W., Lee, M.-C., Tung, Y.-T., Chiu, C.-C., Huang, C.-C., & Huang, W.-C. (2018). The synergistic effects of resveratrol combined with resistant training on exercise performance and physiological adaption. Nutrients, 10(10), 1360.
Muhammad, M. H., & Allam, M. M. (2018). Resveratrol and/or exercise training counteract aging-associated decline of physical endurance in aged mice; targeting mitochondrial biogenesis and function. The Journal of Physiological Sciences, 68(5), 681–688.
Olesen, J., Gliemann, L., Biensø, R., Schmidt, J., Hellsten, Y., &Pilegaard, H. (2014). Exercise training, but not resveratrol, improves metabolic and inflammatory status in skeletal muscle of aged men. The Journal of Physiology, 592(8), 1873–1886.
Ringholm, S., Olesen, J., Pedersen, J. T., Brandt, C. T., Halling, J. F., Hellsten, Y., … Pilegaard, H. (2013). Effect of lifelong resveratrol supplementation and exercise training on skeletal muscle oxidative capacity in aging mice; impact of PGC-1α. Experimental Gerontology, 48(11), 1311–1318.
Rodríguez-Bies, E., Tung, B. T., Navas, P., & López-Lluch, G. (2016). Resveratrol primes the effects of physical activity in old mice. British Journal of Nutrition, 116(6), 979–988.
Ryan, M. J., Jackson, J. R., Hao, Y., Williamson, C. L., Dabkowski, E. R., Hollander, J. M., &Alway, S. E. (2010). Suppression of oxidative stress by resveratrol after isometric contractions in gastrocnemius muscles of aged mice. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 65(8), 815–831.
Scribbans, T. D., Ma, J. K., Edgett, B. A., Vorobej, K. A., Mitchell, A. S., Zelt, J. G., … Gurd, B. J. (2014). Resveratrol supplementation does not augment performance adaptations or fibre-type–specific responses to high-intensity interval training in humans. Applied Physiology, Nutrition, and Metabolism, 39(11), 1305–1313.
Tsao, J.-P., Liu, C.-C., Wang, H.-F., Bernard, J. R., Huang, C.-C., & Cheng, I.-S. (2021). Oral Resveratrol supplementation attenuates exercise-induced Interleukin-6 but not Oxidative Stress after a high intensity cycling challenge in adults. International Journal of Medical Sciences, 18(10), 2137.
Vatavuk-Serrati, G., Alves, R. T., Costa, E. S., Castro, A. G. P. de, & Machado, V. A. (2019). Efeitos da suplementação de resveratrol sobre fatores de risco cardiovascular. Rev. Soc. Cardiol. Estado de Säo Paulo, 88–93.
Voduc, N., La Porte, C., Tessier, C., Mallick, R., & Cameron, D. W. (2014). Effect of resveratrol on exercise capacity: A randomized placebo-controlled crossover pilot study. Applied Physiology, Nutrition, and Metabolism, 39(10), 1183–1187.
Xiao, N.-N. (2015). Effects of resveratrol supplementation on oxidative damage and lipid peroxidation induced by strenuous exercise in rats. Biomolecules&Therapeutics, 23(4), 374.
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